In the present investigation an attempt was made for poorly soluble drug Repaglinide to form a solid dispersion both by solvent evaporation and spray drying method to improve dissolution rate, thus enhancing bio-availability of repaglinide, typically employed polymers like poloxamer 188, PVP-K-30, in varying ratio of 1:1, 1:3and 1:5 prepared by solvent evaporation. The formulation evaluated for in-vitro parameters like drug content and drug release. Based on the drug release formulation 1:1 ratio showed least solubility which was further formulated by Spray dried method using drug and poloxamer188, PVP-k-30 in the 1:1 ratio separately. The Spray dried formulation were carried out for drug content, drug release, FTIR, DSC, XRD, and SEM. Solid state characterization of drug–carrier 1:1 ratio for FTIR showed no any chemical compatibility between the drug and the polymer. Phase solubility studies revealed AL type for each carrier indicating linear increase in solubility with carrier concentration. Good uniformity of drug content was observed in ratios of 1:1, 1:3, 1:5 by solvent evaporation in the range from 85-99% and 1:1 ratio of spray drying showed the drug content ranges from 98-100%. All the solid dispersions showed dissolution improvement as compared to pure drug and physical mixture with faster drug release of 106 % with in 20 min for PVP-k-30 as compare with 104% release with 20 min for Poloxamer 188 this may be due to spray drying method. The stability study indicated that the solid dispersion of drug and carrier were remained stable for a period of 2 months. It was concluded that PVP k 30 is more effective in solubilizing Repaglinide in aqueous media as compared to Poloxamer 188.
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